A study has shown that there may be an association between diet, the gut microbiomeTrusted Source, and lethal Prostate Cancer. The study was conducted by Cleveland Clinic which is published in Cancer Epidemiology, Biomarkers & Prevention.Researchers from the Cleveland clinic used data from the PLCO cancer screening trial trusted Source, a randomized control trial of 148,000 people. It involved screening 76,685 men aged between 55 and 74 for Prostate Cancer and then monitoring them for up to 13 years.
The authors analyzed baseline levels of certain dietary nutrients and metabolites from nearly 700 men. Of these, 173 later died of. The median time between baseline sampling and death for those who developed lethal was 11.69 years.The researchers matched those who died for age, race, time of blood sample, and enrolment date with controls in a ratio of 1:3. Of the 519 men in the control sample, 83.6% remained healthy, and 16.4% had a subsequent non-lethal Prostate Cancer diagnosis during the study period.
The researchers found associations between more aggressive Prostate Cancer and three metabolites – phenylacetylglutamine, choline, and betaine. Phenylacetylglutamine is produced when gut bacteria break down phenylalanine, an essential amino acid. Choline and betaine are in some foods, as well as being formed by gut bacteria.