Osaka City University creates a combination of rifampicin and resveratrol and have shown in mouse models that the Nasal administration improves cognitive function without the negative liver side effects.Dementia occurs when proteins called amyloid-β, tau, and α-synuclein accumulate in the brain and form oligomers.
A research group from the Department of Translational Neuroscience, Osaka City University Graduate School of Medicine, had previously shown in a study using mice that the antibiotic rifampicin removes oligomers from the brain and improves cognitive function. The drug has been associated with side effects such as liver damage. Resveratrol, a naturally occurring antioxidant in plants, is used as a supplement in Europe and the United States.
The blood levels of liver enzymes, a marker of hepatic damage that normally increases with rifampicin, remained normal in the fixed-dose combination.The increased levels of brain-derived neurotrophic factor (BDNF) expression were observed in the hippocampus, which was not seen with rifampicin alone. These results indicate that this fixed-dose combination is superior to rifampicin alone in terms of both safety and efficacy. The results of this study were published online in the Swiss scientific journal Frontiers in Neuroscience on December 13, 2021.